Cefditoren Pivoxil

Cefditoren pivoxil is a third-generation cephalosporin antibiotic.

TOKU-E offers three forms of cefditoren:

Mechanism of Action	Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
Spectrum	Cefditoren is a broad spectrum antibiotic commonly used against bacteria responsible for community acquired pneumonia and pharyngitis
Microbiology Applications	Cefditoren pivoxil can be used to study antibiotic effects against group A Streptococcus and other microbes responsible for phayrngitis.
Molecular Formula	C₂₅H₂₈N₆O₇S₃
Impurities	Single Impurity: ≤0.1% Total Impurities: ≤5.0%
References	Poveda, J. L., et al. "Cefditoren Pivoxil: A New Oral Cephalosporin for Skin, Soft Tissue and Respiratory Tract Infections." Medline 19.3 (n.d.): 231-46.www.ncbi.gov. Web. 27 Aug. 2012. Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.
MIC	Haemophilus influenzae (TUM8)\| 2\|\| Streptococcus pneumonia \| 0.25 - 16\|\|