Cefteram pivoxil is a third generation cephalosporin antibiotic. Cefteram pivoxil contains a pivoxil group which increases lipophilicity. Cefteram pivoxil is freely soluble in ethanol, acetonitrile, methanol, and chloroform.
|Mechanism of Action||Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.|
|Spectrum||Like many third generation cephalosporins, cefteram is mostly active against gram negative bacteria especially those which cause meningitis and gonorrhea.|
|Impurities||Single Impurity: ≤1.5% |
Total Impurities: ≤2.0%
"Serious hypocarnitinemia and hypoglycaemia in Children treated with antibacterials with a Pivoxil group." Pmda.go.jp. N.p., n.d. Web. 8 Apr. 2014.
Fuchs, Tarr. "Case Study: Cefditoren Pivoxil: An Oral Prodrug of Cefditoren." Prodrugs V (2007): 1185-194. Link.springer.com. Web. 8 Apr. 2014.