SKU: C243  / 
    CAS Number: 61270-78-8

    Cefonicid Sodium

    $99.75 - $284.55

    Cefonicid sodium is the disodium salt of Cefonicid. It is a broad-spectrum, second-generation cephalosporin antibiotic that interferes with bacterial cell wall biosynthesis.

    Mechanism of ActionCephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases.
    SpectrumEffective against Gram-positive and Gram-negative bacteria.
    Microbiology ApplicationsCefonicid sodium is effective against E. coli, Klebsiella, Enterobacter, and Citrobacter.
    Eukaryotic Cell Culture ApplicationsThe interaction of cefonicid (and other beta-lactams including cefazolin, cephalothin, ampicillin, and piperacillin) with the purified mitochondrial carnitine/acylcarnitine transporter reconstituted in liposomes has been studied. When added to the proteoliposome, cefonicid was found to competitively inhibit the carnitine/carnitine antiport catalysed by the reconstituted transporter. It was the most effective of the antibiotics tested with an IC50 of 0.12 mM after 60 h of incubation. (Pochini et al 2008)
    Molecular FormulaC18H16N6O8S3 • 2Na
    ReferencesBarry AL, Jones RN, Thornsberry C (1983) Evaluation of the cefonicid disk test criteria, including disk quality control guidelines. J Clin Microbiol. 1983 17(2):232-239 PMID 6601113 Dudley MN, Quintiliani R and Nightingale CH (1984) Review of cefonicid, a long-acting cephalosporin. Clin. Pharm. 3(1):23-32 Kalman D and Barriere SL (1990) Review of the pharmacology, pharmacokinetics, and clinical use of cephalosporins. Texas Heart Inst. J. 17(3):203-215 PMID 15227172 Pochini L et al (2008) Interaction of beta-lactam antibiotics with the mitochondrial carnitine/acylcarnitine transporter. Chem Biol Interact.73(3):187-194 PMID 18452908