Cefradine (also known as cephradine) is a first generation cephalosporin antibiotic which a has similar anti-bacterial spectrum of activity to cefalexin. Cefradine is freely soluble in aqueous solution at 21.3 mg/mL.
| Mechanism of Action | Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. |
| Molecular Formula | C16H19N3O4S•H2O |
| Impurities | 7-ADCA: ≤1.0% Cyclohexa-1,4-dienylglycine: ≤1.00% Cefalexin: ≤5.0% N,N-Dimethylaniline: ≤20ppm Any Other Impurity: ≤1.0% |
| References | Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012. |
| MIC | Bacillus subtilis| 8|| Bacteroides fragilis| 1 － 128|| Burkholderia mallei (Pakistan)| 32 - 128|| Diplococcus pneumoniae| 0.8 － 6.3|| Enterobacter cloacae| >512|| Enterobacteriaceae| 0.25 － 128|| Enterococcus faecalis| 5|| Escherichia coli| 16 - >412.8|| Haemophilus influenzae| 6.3 － 12.5|| Haemophilus spp.| 1 － 128|| Klebsiella baumannii| >512|| Klebsiella pneumonia| >512|| Klebsiella pneumoniae| 10|| Lactobacillus spp.| 576|| Neisseria gonorrhoeae| 0.25 － 32|| Pseudomonas aeruginosa| 17 - >512|| Shigella sp.| 6|| Staphylococci| 0.25 － 128|| Staphylococcus aureus| 2 - >172.7|| Staphylococcus epidermidis| 4|| |