SKU: C019  / 
    CAS Number: mixture

    Ceftazidime Solubilized

    $122.54 - $579.25

    Ceftazidime Solubilized is a semi-synthetic, broad-spectrum, third-generation, β-lactam cephalosporin.   Patented in 1978, it came into commercial use in 1984.   Ceftazidime is bactericidal in action, inhibiting enzymes responsible for bacterial cell-wall synthesis, primarily penicillin binding protein 3 (PBP3). The compound is sparingly soluble in aqueous solution, but acidic and alkali solvents are commonly used to facilitate dissolution.

    We also offer:

    • Ceftazidime Hydrochloride (C020)
    • Ceftazidime Pentahydrate (C059)
    • Ceftazidime, Delta-3-Isomer, EvoPure® (C121)
    Mechanism of Action Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, ceftazidime is stable in the presence of β-lactamases.
    Spectrum Ceftazidime is broad-spectrum, targeting both Gram-negative and Gram-positive bacteria, but is most effective for Gram-negative strains including Pseudomonas aeruginosa.  It is also used against Streptococus pneumoniae, and S. pyogenes.   It is effective against Enterobacteriaceae (including β-lactamase positive strains).
    Microbiology Applications Ceftazidime is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram- negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:
    • Pseudomonas aeruginosa 1 µg/mL – 64 µg/mL
    • Escherichia coli 0.06 µg/mL – >32 µg/mL
    • For a representative list of Ceftazidime MIC values, click here.

    Media Supplements

    Ceftazidime can be used as a selective agent in several types of isolation media:

    PALCAM Agar - PALCAM Selective Supplement

    ChromogenicListeria Agar - Chromogenic Listeria Selective Supplement

    ChromogenicListeria Agar - Chromogenic Listeria Differential Supplement

    Solubility Sparingly soluble in aqueous solution. Organic solvents used to facilitate dissolution.
    References

    Fischer J, Ganellin R (2006) Analogue-based Drug Discovery. John Wiley & Sons. p. 495

    Georgopapadakou NH (1992)  Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents. Chemother. 37(3): 559-565

    Gunther EC et al (2019)  Rescue of transgenic Alzheimer’s pathophysiology by polymeric cellular prion protein antagonists. 26(1):15-158