SKU: C023  / 
    CAS Number: 56238-63-2

    Cefuroxime Sodium

    $108.19 - $361.42

    Cefuroxime Sodium is a broad-spectrum, semi-synthetic second-generation cephalosporin antibiotic with increased stability to β-lactamases.  It is bactericidal against Gram-negative and Gram-positive bacteria.  Cefuroxime Sodium is freely soluble in aqueous solution.

    Mechanism of Action Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many second generation cephalosporins, Cefuroxime is relatively stable in the presence of β-lactamases.
    Spectrum Cefuroxime Sodium is a broad-spectrum antibiotic targeting a wide variety of Gram-negative and Gram-positive bacteria.
    Impurity Profile Individual Impurity: Not more than 1.0%
    Total Impurities: Not more than 3.0%
    Microbiology Applications

    Cefuroxime Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.

    Representative MIC values include:

    • Haemophilus influenzae 0.25 µg/mL – 4 µg/mL
    • Neisseria gonorrhoeae 0.2 µg/mL – 1.6 µg/mL
    • For a representative list of Cefuroxime MIC values, click here.
    Eukaryotic Cell Culture Applications Rat erythrocyte glucose-6-phosphate dehydrogenase was found to increase in activity in response to Cefuroxime exposure in vitro (Temel Y et al, 2018). 

    Cell proliferation, cytotoxicity, cell metabolism, and extracellular matrix calcification were assessed after antibiotic treatment. Cefuroxime had no inhibiting effects on osteoblasts with lower concentrations (25-100 ug/ml), but higher concentrations (250-1000 µg/ml) saw an increase in cell proliferation and cytotoxicity, and an inhibition of cell metabolism (Salzmann et al, 2007).
    Molecular Formula C16H15N4NaO8S
    References Georgopapadakou NH (1992) Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents Chemother. 37(3): 559-565

    O'Callaghan CH, Sykes RB, Griffiths A, Thornton JE (1976) Cefuroxime, a new cephalosporin antibiotic: Activity in vitro. Antimicrob. Agents Chemother. 9(3):511-519  PMID 1259407

    Salzmann GM (2007) Effects of Cefuroxime on human osteoblasts in vitro. J. Biomed. Mat. Res. 82A(2):462-468

    Temel Y, Ayna A, Shafeeq IH and Ciftci M (2018) In vitro effects of some antibiotics on glucose-6-phosphate dehydrogenase from rat (Rattus norvegicus) erythrocyte. Drug Chem. Toxicol. ePub. doi: 10.1080/01480545 PMID 29947262
    MIC Bacteroides bivius| 0.5 - >64|| Bacteroides disiens| 0.5 - >64|| Bacteroides distasonis| 0.5 - >64|| Bacteroides fragilis| 0.5 - >400|| Bacteroides melaninogenicus| 1.6|| Bacteroides ovatus| 0.5 - >64|| Bacteroides thetaiotaomicron| 0.5 - >64|| Bacteroides vulgatus| 0.5 - >64|| Borrelia afzelii | 0.125 - 0.25|| Borrelia bissettii| 0.125|| Borrelia burgdorferi| 0.06 - 0.5|| Borrelia garinii | 0.06 - 0.125|| Borrelia valaisiana (VS116)| 0.25|| Branhamella catarrhalis| 0.25 - 2|| Brucella abortus| 4|| Brucella melitensis| 4|| Brucella suis| 4|| Burkholderia mallei (Pakistan)| 64 - 128|| Citrobacter| 1.6 - 400|| Citrobacter diversus| 2 - >32|| Citrobacter freundii| 1 - >128|| Citrobacter koseri| ≤0.25 - 8|| Clostridium| 0.4 - 1.6|| Clostridium difficile| 64 - >64|| Clostridium histolyticum | 0.5 - 4|| Clostridium perfringens| 0.5 - 4|| Clostridium sordellii| 0.5 - 4|| Clostridium sporogenes| 0.5 - 4|| Edwardsiella hoshinae | ≤0.03 - 0.06|| Edwardsiella ictaluri | ≤0.03 - 0.25|| Edwardsiella tarda| ≤0.03 - 4|| Eikenella corrodens| 0.5 - 8|| Enterobacter| 0.8 - ≥400|| Enterobacter aerogenes| 2 - 256|| Enterobacter agglomerans| ≤0.25 - 16|| Enterobacter cloacae| 2 - >64|| Enterobacter sakazakii| ≤0.25 - 16|| Enterobacter spp.| 1 - ≥128|| Enterobacteriaceae| 0.03 - 128|| Enterococci| 2 - 128|| Enterococcus faecalis| 8 - >128|| Enterococcus faecium| >64|| Enterococcus liquefaciens | >64|| Enterococcus spp.| ≥32|| Escherichia coli| 0.12 - 1024|| Fusobacterium| 1.6|| Fusobacterium| 1.6|| Haemolytic streptococci| 0.008 - 0.12|| Haemophilus influenzae| ≤0.06 - 32|| Haemophilus parainfluenzae| 0.13 - 1|| Haemophilus spp.| 0.25 - 16|| Hafnia alvei| 2 - 16|| Helicobacter pylori| 0.008 - 8|| Klebsiella| 0.8 - 6.2|| Klebsiella oxytoca| 1 - 8|| Klebsiella pneumonia| ≤0.25 - 512|| Klebsiella spp.| ≤0.12 - >128|| Listeria | 0.4|| Listeria innocua| 1 - >64|| Listeria ivanovii| 1 - >64|| Listeria monocytogenes| 1 - >64|| Listeria seeligeri| 1 - >64|| Listeria welshimeri| 1 - >64|| Moraxella catarrhalis| ≤0.06 - 8|| Morganella morganii| 0.12 - 256|| Morganella spp.| 1 - >128|| Neisseria gonorrhoeae| 0.002 - 2|| Neisseria meningitidis| ≤0.2 - 0.8|| Neisseria spp.| 0.008 - 1|| Ochrobactrum anthropi (SLO74)| ≥128|| Pasturella multocida | 0.4 - 0.8|| Pneumococci| 0.015 - 8|| Proteus| 12.5 - 85|| Proteus mirabilis| 0.25 - 512|| Proteus morganii| 6.2 - 400|| Proteus rettgeri| 0.4 - >400|| Proteus spp. (indole-positive)| 0.25 - >128|| Proteus vulgaris| 1 - 1024|| Providencia| 1.6 - 400|| Providencia rettgeri| 0.12 -64|| Providencia spp.| 0.06 ->128|| Providencia stuartii| 0.5 - >32|| Pseudomonas| >400|| Pseudomonas aeruginosa| >32 - 1024|| Pseudomonas cepacia| 8 - >64|| Pseudomonas flourescens| 8 - >64|| Pseudomonas putida| 8 - >64|| Pseudomonas spp.| 16 - 210|| Pseudomonas stutzeri| 8 - >64|| Ralstonia pickettii| 0.5|| Salmonella| 3.1 - 12.5|| Salmonella Agona| 0.5 - 4|| Salmonella Brandenburg| 0.5 - 4|| Salmonella enteritidis| 0.5 - 8|| Salmonella spp.| ≤0.25 - 8|| Salmonella typhimurium| 0.5 - 4|| Serratia| 3.1 - >400|| Serratia liquefaciens| 16 - >64|| Serratia marcescens| 1 - 512|| Serratia spp.| 1 - >128|| Shigella| 0.4 - 50|| Shigella boydii| 2 - 4|| Shigella dysenteriae (6 + ESBL + multidrug-resistant)| 1024|| Shigella flexneri| 1 - 64|| Shigella sonnei| 1 - 256|| Shigella spp.| 2 - 8|| Staphylococci| 0.25 - 64|| Staphylococcus aureus| 0.25 - >128|| Staphylococcus cohnii| 0.5 - 4|| Staphylococcus epidermidis| ≤0.12 - >32|| Staphylococcus haemolyticus (methicillin-resistant)| 0.5 - >64|| Staphylococcus hominis| 0.25 - 1|| Staphylococcus saprophyticus| 0.25 - >128|| Staphylococcus simulans| 0.25 - 1|| Staphylococcus spp. (coagulase-negative)| ≤0.12 - >32|| Staphylococcus warneri| 0.25 - 0.5|| Stenotrophomonas maltophilia| 32|| Streptococci| ≤0.004 - 64|| Streptococcus agalactiae| 0.06 - 0.4|| Streptococcus bovis| ≤0.2|| Streptococcus faecalis| 6.2 - 25|| Streptococcus milleri | 0.03 - 0.5|| Streptococcus mitior| 0.03 - 0.13|| Streptococcus pneumonia| 0.004 - >16|| Streptococcus pyogenes| 0.008 - 0.5|| Streptococcus viridans| ≤0.2|| Xanthomonas maltophilia| 2 - >64|| Yersinia enterocolitica| 1 - 8||