Cephapirin is a first-generation cephalosporin that boasts broad spectrum activity against gram-positive and gram-negative organisms. It is more resistance to beta-lactamases than the penicillin family. It is commonly used in the veterinary field.
Cephapirin benzathine is practically insoluble in water, ether, and toluene.
Cephapirin benzathine is practically insoluble in water, ether, and toluene.
| Mechanism of Action | Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. |
| Molecular Formula | C34H34N6O12S4 · C16H20N2 |
| References | CEPHAPIRIN (Veterinary—Intramammary-Local) (2003) The United States Pharmacopeial Convention, Inc. Monograph. American Academy of Veterinary Pharmacology and Therapeutics. Website. |