Cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent isolated from Cercosporidium henningsii.
Cercosporamide is soluble in ethanol, methanol, DMF and DMSO.
Cercosporamide is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both a potent (IC50<50nM) and selective inhibitor of Pkc1 kinase. |
| References | Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Sussman A. et al. Eukaryot Cell. 2004, 3, 932. Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong Z. et al. Mol. Cell Biol. 1994, 14, 1017. The structure and biological activity of cercosporamide from Cercosporidium henningsii. Sugawara F. et al. J. Org. Chem. 1991, 56, 909. |