Chaetoglobosin A is a mycotoxin of the cytochalasin class produced by Chaetonium globosum. Like other cytochalasins, chaetoglobosin A has a broad biological profile with antitumor, nematocidal, antifungal, antibiotic and antiamebic activity. Chaetoglobosin A targets the cytoskeleton of chronic lymphocytic leukemia cells, inducing apoptosis.
| Molecular Formula | C32H36N2O5 |
| References |
Knudsen PB et al (2014) Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia 28:1289 Yang et al (2013) Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. J Ag Food Chem. 61:41 Zhang G et al (2013) Antifungal metabolites produced by Chaetomium globosum No.04, an endophytic fungus isolated from Ginkgo biloba. Indian J. Microbiol. 53:175 |