Chaetoviridin A, an azaphilone isolated from Chaetomium sp., is a potent antifungal against plant pathogenic fungi in vitro and in vivo, suppressing the development of rice blast and wheat leaf rust by over 80% at a concentration of 62.5 mcg/mL. Chaetoviridin A has antitumor properties and inhibits tumor promotion induced by 12-O-tetradecanoylphorbol-13-acetate via an anti-inflammatory effect. Chaetoviridin A has moderate inhibitory activity against cholesteryl ester transfer protein (CETP).
| Molecular Formula | C23H25ClO6 |
| References |
Park JH et al (1999) Antifungal activity against plant pathogenic fungi of chaetoviridins isolated from Chaetomium globosum. J. Antibiot. 52:160 Wang et al (2020) Cytotoxic nitrogenated azaphilones from the deep-sea-derived fungus Chaetomium globosum MP4-S01-7. J. Nat. Prod. 83:1157 Yasukawa et al (1994) Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice. Oncol. 51:108 |