Chrysomycin B is a minor analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumor active and an inhibitor of the catalytic activity of human topoisomerase II.
Chrysomycin B is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
Chrysomycin B is soluble in DMF and DMSO and is moderately soluble in methanol or ethanol.
| Mechanism of Action | The mechanism of action of chrysomycins is not fully understood; however, recent research suggests chrysomycins may act as photoactivated cross-linkers of DNA to histones. |
| References | Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of human topoisomerase II. Lorico A. et al. , Eur. J. Cancer. 1993, 29A, 1985. Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. et al. Cancer Res. 2000, 60, 3921. |
