Cidofovir Dihydrate is the dihydrate of Cidofovir a nucleoside analog and antiviral compound and has been used to study cytomegalovirus (CMV) retinitis in HIV research studies. It also has anti-cancer properties.
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| Mechanism of Action | Cidofovir targets CMV DNA polymerase and is active at a concentration of 0.1 µg/mL. |
| Spectrum | Cidofovir Dihydrate has a broad spectrum of antiviral activity against nearly all DNA viruses including poxviruses, papillomaviruses, adenoviruses, and herpesviruses. Cidofovir also targets HPV oncoproteins E6 and E7 which restores the antitumor function of p53. |
| Impurity Profile | Enantiomeric Excess: Not less than 98.0% HPLC: Not less than 99.0% |
| Molecular Formula | C8H14N3O6P · H20 |
| Impurity Profile | Enantiomeric Excess: Not less than 98.0% HPLC: Not less than 99.0% |
| References |
Abdulkarim B et al (2002) Antiviral agent Cidofovir restores P53 function and enhances the radiosensitivity in HPV-associated cancers. Oncogene 21(15):2334-2346 Clercq E (2002) Cidofovir in the treatment of poxvirus infections. Antivir. Res. 55(1):1-13 |
