SKU: C175  / 
    CAS Number: 110655-58-8

    Cinnamycin

    $235.00 - $819.00
    Cinnamycin
    • Detailed Description

      CAS Number: 110655-58-8

      Molecular Formula: C89H125N25O25S3

      Molecular Weight: 2041.3

      Mechanism of Action: Cinnamycin is a potent indirect inhibitor of phospholipase A2, acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane reorganisation including membrane fusion and alteration of gross morphology.

      Storage Conditions: -20°C

    • Specifications

      Appearance: White to off white solid

      Purity Level: >95% by HPLC

    • References

      References: Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin. Naruse N. J. Antibiot. 1989, 42, 837.

      Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin. Fredenhagen A. et al. J. Antibiot. 1990, 43, 1403.

      Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2. Märki F. et al. Biochem. Pharmacol. 1991, 42, 2027.

    Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium.

    Cinnamycin is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number: 110655-58-8

    Molecular Formula: C89H125N25O25S3

    Molecular Weight: 2041.3

    Mechanism of Action: Cinnamycin is a potent indirect inhibitor of phospholipase A2, acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane reorganisation including membrane fusion and alteration of gross morphology.

    Storage Conditions: -20°C

    Appearance: White to off white solid

    Purity Level: >95% by HPLC

    References: Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin. Naruse N. J. Antibiot. 1989, 42, 837.

    Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin. Fredenhagen A. et al. J. Antibiot. 1990, 43, 1403.

    Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2. Märki F. et al. Biochem. Pharmacol. 1991, 42, 2027.