Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of Streptoverticillium.
Cinnamycin is soluble in ethanol, methanol, DMF and DMSO.
Cinnamycin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Cinnamycin is a potent indirect inhibitor of phospholipase A2, acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane reorganisation including membrane fusion and alteration of gross morphology. |
| Molecular Formula | C89H125N25O25S3 |
| References | Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin. Naruse N. J. Antibiot. 1989, 42, 837. Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin. Fredenhagen A. et al. J. Antibiot. 1990, 43, 1403. Mode of action of the lanthionine-containing peptide antibiotics duramycin, duramycin B and C, and cinnamycin as indirect inhibitors of phospholipase A2. Märki F. et al. Biochem. Pharmacol. 1991, 42, 2027. |