Corynecin III (methamphenicol) is a member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from Corynebacterium hydrocarboclastus in 1972. Corynecin III is active against Gram positive and Gram negative bacteria. Although less potent than chloramphenicol, corynecin III shows a similar species selectivity. Corynecin III was used as a bioisostere of chloroamphenicol to examine the binding relationship of chloramphenicols to DraE virulence factor.
Corynecin III is soluble in ethanol, methanol, DMF and DMSO.
Corynecin III is soluble in ethanol, methanol, DMF and DMSO.
| Molecular Formula | C13H18N2O5 |
| References | Production of antibacterial compounds analogues to chloramphenicol by a n-paraffin-grown bacterium. Suzuki T. et al. Agri. Biol. Chem. 1972, 36, 2223. The structure of corynecins; chloramphenicol by a n-paraffin-grown bacterium. Shirahata K. et al. Agri. Biol. Chem. 1972, 36, 2229. A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol. Pettigrew D.M. et al. Acta Cryst. Set. D 2009, 65, 513. |
