SKU: C044  / 
    CAS Number: 59787-61-0

    Cyclosporin C, EvoPure®

    $263.50
    Cyclosporin C, EvoPure®
    • Detailed Description

      CAS Number: 59787-61-0

      Molecular Formula: C62H111N11O13

      Molecular Weight: 1218.6 g/mol

      Mechanism of Action: Cyclosporin C and other metabolites of Cyclosporin A have lower immunosuppressant activity but most likely operate under the same mechanism as Cyclosporin A.  Cyclosporin A immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, Cyclosporin A associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A:cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and T-cell activation.

      Storage Conditions: -20 °C

      Tariff Code: 2933.79.8500

    • Applications

      Cancer Applications: Cyclosporin metabolites can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.

    • Specifications

      Form: Powder

      Appearance: Colorless prismatic needle

      Source: Tolypocladium Inflatum

      Water Content (Karl Fischer): 3.0%

      Heavy Metals: ≤0.02%

      Melting Point: 152-155 °C

      Purity Level: ≥95.0%

    • Technical Data

      Impurities: Total: ≤5.0%

    • References

      References:

      Copeland KR, Yatscoff RW and McKenna RM (1990)  Immunosuppressive activity of Cyclosporine metabolites compared and characterized by mass spectrometry and nuclear magnetic resonance. Clin. Chem. 36(2):225-229 PMID 2137384 

      Ho S et al (1996)  The mechanism of action of Cyclosporin A and FK506. Clin. Immunol. and Immunother.  80(3 Pt 2):S40-5  PMID 8811062

      Laupacis A, Keown PA, Ulan RA, McKenzie N and Stiller CR (1982) Cyclosporin A: A powerful immunosuppressant.  Can. Med. Assoc.  126(9): 1041-1046  PMID 7074504

      Matsuda S and Koyasu S (2000)  Mechanisms of action of Cyclosporine.  Immunopharmacol. 47(2-3):119-125  PMID 10878286

        Wang CP et al (1989)  Isolation of 10 Cyclosporine metabolites from human bile. Drug Metab. and Disposition 17 (3):292-296  PMID 2568911

      Cyclosporin C, EvoPure® is a hydroxylated metabolite of Cyclosporin A.  Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A.  Cyclosporin C also has antimycotic properties.

      EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.

      For more Cyclosporin products, click here.

      CAS Number: 59787-61-0

      Molecular Formula: C62H111N11O13

      Molecular Weight: 1218.6 g/mol

      Mechanism of Action: Cyclosporin C and other metabolites of Cyclosporin A have lower immunosuppressant activity but most likely operate under the same mechanism as Cyclosporin A.  Cyclosporin A immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, Cyclosporin A associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A:cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and T-cell activation.

      Storage Conditions: -20 °C

      Tariff Code: 2933.79.8500

      Cancer Applications: Cyclosporin metabolites can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments.

      Form: Powder

      Appearance: Colorless prismatic needle

      Source: Tolypocladium Inflatum

      Water Content (Karl Fischer): 3.0%

      Heavy Metals: ≤0.02%

      Melting Point: 152-155 °C

      Purity Level: ≥95.0%

      Impurities: Total: ≤5.0%

      References:

      Copeland KR, Yatscoff RW and McKenna RM (1990)  Immunosuppressive activity of Cyclosporine metabolites compared and characterized by mass spectrometry and nuclear magnetic resonance. Clin. Chem. 36(2):225-229 PMID 2137384 

      Ho S et al (1996)  The mechanism of action of Cyclosporin A and FK506. Clin. Immunol. and Immunother.  80(3 Pt 2):S40-5  PMID 8811062

      Laupacis A, Keown PA, Ulan RA, McKenzie N and Stiller CR (1982) Cyclosporin A: A powerful immunosuppressant.  Can. Med. Assoc.  126(9): 1041-1046  PMID 7074504

      Matsuda S and Koyasu S (2000)  Mechanisms of action of Cyclosporine.  Immunopharmacol. 47(2-3):119-125  PMID 10878286

        Wang CP et al (1989)  Isolation of 10 Cyclosporine metabolites from human bile. Drug Metab. and Disposition 17 (3):292-296  PMID 2568911