Cyclosporin C, EvoPure® is a hydroxylated metabolite of Cyclosporin A. Cyclosporin C has similar immunosuppressant activity, but lower nephrotoxicity than Cyclosporin A. Cyclosporin C also has antimycotic properties.
EvoPure® products have been fully characterized by spectral analysis and are shipped with a comprehensive certificate of analysis containing lot-specific HPLC, MS, HNMR, and FTIR data.
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| Mechanism of Action | Cyclosporin C and other metabolites of Cyclosporin A have lower immunosuppressant activity but most likely operate under the same mechanism as Cyclosporin A. Cyclosporin A immunosuppressant activity stems from its ability to prevent T-cell activation by blocking specific cytokine transcription genes. After entering a T-cell, Cyclosporin A associates with ubiquitous cytosolic proteins called cyclophilins which aid in protein folding. Cyclosporin A:cyclophilin complexes together bind calcineurin, (another cytosolic protein) effectively blocking the pathway to IL-2 gene transcription and T-cell activation. |
| Cancer Applications | Cyclosporin metabolites can be used to study toxicity and immunosuppressant activity in various in vitro assays and experiments. |
| Molecular Formula | C62H111N11O13 |
| References | Copeland KR, Yatscoff RW and McKenna RM (1990) Immunosuppressive activity of Cyclosporine metabolites compared and characterized by mass spectrometry and nuclear magnetic resonance. Clin. Chem. 36(2):225-229 PMID 2137384 Ho S et al (1996) The mechanism of action of Cyclosporin A and FK506. Clin. Immunol. and Immunother. 80(3 Pt 2):S40-5 PMID 8811062 Laupacis A, Keown PA, Ulan RA, McKenzie N and Stiller CR (1982) Cyclosporin A: A powerful immunosuppressant. Can. Med. Assoc. 126(9): 1041-1046 PMID 7074504 Matsuda S and Koyasu S (2000) Mechanisms of action of Cyclosporine. Immunopharmacol. 47(2-3):119-125 PMID 10878286 Wang CP et al (1989) Isolation of 10 Cyclosporine metabolites from human bile. Drug Metab. and Disposition 17 (3):292-296 PMID 2568911 |
