Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.
Cytochalasin E is soluble in ethanol, methanol, DMF and DMSO.
Cytochalasin E is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | All cytochalasins exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. |
| References | The structure of the fungal metabolites cytochalasins E and F. Aldridge D. C. et al. Chem. Commun. 1973, 551. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Udagawa T. et al. J. Pharmacol. Exp. Ther. 2000, 294, 421. |
