Demethylbleomycin A2 Sulfate, EvoPure® (Bleomycin impurity D) is a demethylated form of Bleomycin A2 - a major component in standard grade Bleomycin. Demethylbleomycin A2 is formed by heating Bleomycin A2. Demethylbleomycin A2 comprises approximately 3.0% of standard grade Bleomycin. Demethylbleomycin A2 has been found to have high antimicrobial activity against Mycobacterium smegmatis compared to Bleomycin A2. Additionally, demethylbleomycin A2 has a lower toxicity profile and greater antitumor properties than Bleomycin A2.
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