Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-?. Dinactin has not previously been available for intensive investigation.
Dinactin is soluble in ethanol, methanol, DMF and DMSO.
Dinactin is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. |
| References | Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S.P. et al. , Am. J. Respir. Cell Mol. Biol., 1999, 20, 481. Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y. et al. , Jpn. J. Ophthalmol., 1987, 31, 218. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S.N., et al. , Biochemistry, 1966, 5, 1735. |