Drimenol is a sesquiterpene drimane first isolated from members of the Canellaceae family. More recently, Drimenol was
prepared semi-synthetically from polygodial isolated from the Australian tree, Tasmannia lanceolata, by Smith and colleagues at the University of Tasmania, Australia. Drimenol possesses antifungal, insect anti-feedant and larval growth regulatory activity.
| Molecular Formula | C15H26O |
| References | Derita M et al (2013) Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Molecules 18:2029 Jansen BJM and de Grot A (2004) Occurrence, biological activity and synthesis of drimane sesquiterpenoids. Jansen B.J.M. & de Groot Ae., Nat.Prod. Rep. 21:449 Just J et al (2015) Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis. Org. Biomol. Chem., 13:11200 Montenegro IJ et al (2018) Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and Epilachna paenulata and quantitative structure-activity analysis. Pest Manag. Sci. 74:1623 Montenegro I et al (2013) Comparative study on the larvicidal activity of drimane sesquiterpenes and nordrimane compounds against Drosophila melanogaster til-til. Molecules 18:4192 Robles-Kelly C et al (2017) Effect of drimenol and synthetic derivatives on growth and germination of Botrytis cinerea: Evaluation of possible mechanism of action. Pestic. Biochem. Physiol. 141:50 |