SKU: E001  / 
    CAS Number: 68797-31-9

    Econazole Nitrate

    $60.28 - $573.68

    Econazole Nitrate is an imidazole antimycotic agent similar to ketoconazole.  The compound targets the fungal cell membrane. It can be used as an analytical standard.  Econazole Nitrate is practically insoluble in water.

    Mechanism of Action Econazole Nitrate increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The permeability has toxic effects and leads to fungal cell death.
    Spectrum Econazole Nitrate targets fungi responsible for tinea (ringworm) especially Trichophyton and Microsporum.  It also targets Gram-positive bacteria.
    Molecular Formula C18H15Cl3N2O · HNO3
    References

    Bygrave FL, Fulceri R, and Benedetti A (1998) On the mechanism of action of Econazole, the capacitative calcium inflow blocker. 248(1):75-77  PMID 9675088

    Jansook P, Prajapati M, Pruksakorn P, Loftsson T (2019)  Antifungal activity of Econazole nitrate/cyclodextrin complex: Effect of pH and formation of complex aggregates. Int. J. Pharm. 574:118896  PMID 31765779

    Rice, LB and Ghannoum MA (1999)  Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 12(4):501-17