Econazole Nitrate is an imidazole antimycotic agent similar to ketoconazole. The compound targets the fungal cell membrane. It can be used as an analytical standard. Econazole Nitrate is practically insoluble in water.
| Mechanism of Action | Econazole Nitrate increases cell permeability by inhibiting enzymes involved in ergosterol synthesis. The permeability has toxic effects and leads to fungal cell death. |
| Spectrum | Econazole Nitrate targets fungi responsible for tinea (ringworm) especially Trichophyton and Microsporum. It also targets Gram-positive bacteria. |
| Molecular Formula | C18H15Cl3N2O · HNO3 |
| References |
Bygrave FL, Fulceri R, and Benedetti A (1998) On the mechanism of action of Econazole, the capacitative calcium inflow blocker. 248(1):75-77 PMID 9675088 Jansook P, Prajapati M, Pruksakorn P, Loftsson T (2019) Antifungal activity of Econazole nitrate/cyclodextrin complex: Effect of pH and formation of complex aggregates. Int. J. Pharm. 574:118896 PMID 31765779 Rice, LB and Ghannoum MA (1999) Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 12(4):501-17 |
