Emeguisin A was first isolated from the fungus Emericella unguis by Yamakazaki and coworkers from Hoshi University, Japan in 1988. Emeguisin A exhibits potent antibacterial activity against Staphylococcus aureusincludin methicillin-resistant strains, as well as strong antifungal activity against Cryptococcus neoformans, each with MIC values of 0.5 μg/mL.
| Molecular Formula | C23H23ClO5 |
| References |
Kawahara N et al (1988) Studies on fungal products. Part 22. Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguis. KChem Soc Perkin Trans I Org Bioorg Chem. 9:2611 Klaiklay S et al (2016) Depsidone and phthalide derivatives from the soil-derived fungus Asperguillus unguis PSU-RSPG199. Tet Lett. 2016, 57:4348 Morshed MT et al (2018) Expanding the chemical space around the nidulin pharmacophore. Org Biomolec Chem. 16:3038 |