Emestrin is a macrocyclic mycotoxin first isolated from Emericella striata by researchers at Hoshi Unveristy, Japan in 1985. Emestrin posseses a unique epidithiodioxopiperazine ring as part of a larger heterologous macrocycle. Emestrin inhibits mitochondrial ATP synthesis via uncoupling of oxidative phosphorylation and depression of mitochondrial respiration. Emestrin is a potent antagonist of the chemokine CCR2 receptor, via inhibition of MCP-1 binding, specifically mediating monocyte chemotaxis.
| Molecular Formula | C27H22N2O10S2 |
| References | Herath KB et al (2005) Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists. J. Antibiot. 58:686 Hideyuki S et al (1985) Structure and absolute configuration of Emestrin, a new macrocyclic epidithiodioxopiperazine from Emericella striata. J. Chem. Soc. 10:657 Kawai K et al (1989) Toxicity of Emestrin, a new macrocyclic dithiodioxopiperazine mycotoxin, to mitochondrial function. Mycotox. Res. 5:2 |