SKU: E087  / 
    CAS Number: 97816-62-1

    Emestrin

    3,884,606.71₫ - 13,596,123.49₫

    Emestrin is a macrocyclic mycotoxin first isolated from Emericella striata by researchers at Hoshi Unveristy, Japan in 1985.  Emestrin posseses a unique epidithiodioxopiperazine ring as part of a larger heterologous macrocycle. Emestrin inhibits mitochondrial ATP synthesis via uncoupling of oxidative phosphorylation and depression of mitochondrial respiration. Emestrin is a potent antagonist of the chemokine CCR2 receptor, via inhibition of MCP-1 binding, specifically mediating monocyte chemotaxis.

    Molecular Formula  C27H22N2O10S2
    References

    Herath KB et al (2005)  Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists. J. Antibiot. 58:686

    Hideyuki S et al (1985)  Structure and absolute configuration of Emestrin, a new macrocyclic epidithiodioxopiperazine from Emericella striata. J. Chem. Soc. 10:657

    Kawai K et al (1989)  Toxicity of Emestrin, a new macrocyclic dithiodioxopiperazine mycotoxin, to mitochondrial function. Mycotox. Res. 5:2