Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram positive and Gram negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B.
Enopeptin A is soluble in ethanol, methanol, DMF or DMSO.
Enopeptin A is soluble in ethanol, methanol, DMF or DMSO.
| Mechanism of Action | Like other acyldepsipeptide (ADEP) antibiotics, Enopeptin A acts by activating and disregulating Clp-family proteins. |
| Molecular Formula | C47H57N7O11 |
| References | The structure of enopeptins A and B, novel depsipeptide antibiotics. Koshino H. et al. Tetrahedron Letters 1991, 32, 7707. Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. Osada H. et al. J. Antibiot. 1991, 44, 1436. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al. Nature Struct. Mol. Biol. 2010, 17, 471. Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. Hinzen B. et al. Chem. Med. Chem. 2006, 1, 689. |
