Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram-positive and Gram-negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B.
Enopeptin A is soluble in ethanol, methanol, DMF or DMSO.
| Mechanism of Action | Like other acyldepsipeptide (ADEP) antibiotics, Enopeptin A acts by activating and disregulating Clp-family proteins. |
| Molecular Formula | C47H57N7O11 |
| References |
Hinzen B et al (2006) Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. . Chem. Med. Chem. 1:689 Koshino H. et al (1991) The structure of enopeptins A and B, novel depsipeptide antibiotics. Tetrahedron Letters 32:7707 Lee B-G. et al (2010) Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nature Struct. Mol. Biol. 17:471 |