Enramycin B, EvoPure® is a highly purified form of Enramycin B. Enramycin is a polypeptide antibiotic produced by Streptomyces fungicidus and developed as a food additive in Japan. Enramycin is composed of two different compounds: Enramycin A Enramycin B. The ratios of A and B varies but is typically ~70:30. Enramycin is slightly soluble in water and freely soluble in dilute HCl solution.
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|Mechanism of Action||Enramycin acts as a MurG inhibitor involved peptidoglycan synthesis in Gram-positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibition of this step greatly compromises cell wall integrity leading to cell death by lysis.|
|Spectrum||Enramycin is effective against Gram-positive bacteria and inhibits development of major gut flora pathogens. Resistance or cross-resistance with existing antibiotics has rarely been observed.|
|Solubility||Slightly soluble in water. Freely soluble in dilute HCl solution.|
|References||Fang X et al (2006) The mechanism of action of ramoplanin and Enduracidin. Royal Soc. Chem. 2: 69-76 PMID 16880924|