SKU: E016  / 
    CAS Number: 93106-60-6

    Enrofloxacin

    $261.49 - $1,059.76

    Enrofloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine.

    TOKU-E offers two forms of enrofloxacin, enrofloxacin (E016) and enrofloxacin HCl (E007). Enrofloxcin is slightly soluble in aqueous solution and enrofloxacin HCl is freely soluble at 10 mg/mL.

    Mechanism of ActionFluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.
    SpectrumEnrofloxacin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria and a few Mycoplasma species.
    Impurity ProfileImpurity A| 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity B| ciprofloxacin|||| Impurity C| 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity E| 6-chloro-1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid|||| Impurity F| 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoroquinolin-4(1H)-one|||| Impurity G| 7-[(2-aminoethyl)amino]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid||||
    Microbiology ApplicationsEnrofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive, gram negative, and certain Mycoplasma species. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Pseudomonas aeruginosa 0.5 µg/mL – 2 µg/mL
    • Escherichia coli 0.004 µg/mL – 0.03 µg/mL
    • For a complete list of enrofloxacin MIC values, click here.
    Molecular FormulaC19H22FN3O3
    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

    MICAeromonas hydrophila| 0.06 - >0.4 || Aeromonas salmonicida subsp. salmonicida| 0.0047 - 0.06 || Burkholderia mallei| 2 - 4|| Enterococcus| 0.5 - 8 || Enterococcus faecalis| 0.39 - 25 || Enterococcus faecium| 0.05 - 12.5 || Enterococcus hirae| 0.2 - 6.25 || Escherichia coli| 0.008 - 512 || Haemophilus parasuis| 0.12 - 8 || Lactobacillus acidophilus| 16 - 128 || Lactobacillus buchneri | 8 - 16|| Lactobacillus plantarum| 0.125 - 16 || Lactobacillus reuteri| 4 - 32|| Lactobacillus rhamnosus| 4 - 8|| Lactobacillus salivarius | 4 - 16|| Lactococcus | 0.5 - 8 || Leuconostoc | 0.5 - 8 || Mannheimia haemolytica| 0.007 - 0.125 || Mycoplasma bovis| 0.06 - 2 || Mycoplasma fermentans| <0.49 || Mycoplasma gallisepticum| 0.01 - >32 || Mycoplasma hyopneumoniae| 0.015 - >1 || Mycoplasma hyorhinis| 1.95|| Mycoplasma hyosynoviae| 0.05 - 0.5 || Mycoplasma iowae| 0.03 - 1 || Mycoplasma meleagridis| 0.015 - 3.13 || Mycoplasma synoviae | 0.025 - >32 || Pasteurella haemolytica| 0.03|| Pasteurella multocida| 0.00375 - 0.125 || Pediococcus | 0.5 - 8 || Pseudomonas aeruginosa| 0.5 - 2 || Rhodococcus equi| 0.03 - >4 || Salmonella typhimurium| 0.03|| Staphylococcus| ≤0.25 - 2 || Staphylococcus aureus| 0.0925 - 64 || Staphylococcus intermedius| 0.03 - 0.25 || Streptococcus bovis| 1 - 16|| Streptococcus infantarius | 1 - 16|| Weissella spp.| 1 - 16||