Entecavir is a deoxyguanosine analog antiviral used in hepatitis B (HBV) research.
| Mechanism of Action | Entecavir inhibits DNA synthesis by targeting HBV reverse transcriptase. |
| Impurity Profile | Single impurity: Not more than 0.1% Total impurities: Not more than 0.3% |
| Molecular Formula | C12H15N5O3 |
| Impurity Profile | Single impurity: Not more than 0.1% Total impurities: Not more than 0.3% |
| Residual Solvents | Tetrahydrofuran: Not more than 720ppm Methanol: Not more than 1000ppm Ethyl Acetate: Not more than 5000ppm |
| References | Menéndez-Arias, Luis, Mar Álvarez, and Beatriz Pacheco. "Nucleoside/nucleotide Analog Inhibitors of Hepatitis B Virus Polymerase: Mechanism of Action and Resistance." Current Opinion in Virology 8 (2014): 1-9. Web. |