Eprinomectin B1b is a semi-synthetic analogue of avermectin B1b prepared by oxidation of the 4-hydroxy moiety and reductive amination followed by acetylation. Eprinomectin B1b is the minor component (<10%) of the commercial product for endo- and exo-para
| Solubility | Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. |
| References | 4-Keto- and 4-amino-4-deoxy avermectin compounds and substituted amino derivatives thereof. Mrozik H.H. et al., 1984 US Patent 4,427,663. Synthesis of 4"-epi-amino-4"-deoxyavermectins B1. Cvetovich R.J. et al., J. Org. Chem. 1994, 59, 7704. Efficacy in sheep and pharmacokinetics in cattle that led to the selection of eprinomectin as a topical endectocide for cattle. Shoop W.L. et al., Int. J. Parasitol. 1996, 26, 1227. |
