SKU: A139  / 
    CAS Number: 65195-56-4

    Avermectin B1b

    $314.94 - $1,102.28
    Avermectin B1b is the minor component (<20%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1b contains an isopropyl residue in the 25-position. In vitro and in vivo studies have shown this analogue to be active, but less potent than the B1a analogue.

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    ReferencesAvermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al. et al. Proc Natl Acad Sci U S A. 1979, 76, 2062.

    Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans.Cully D.F. et al. Mol Pharmacol. 1991, 40, 326.

    Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.Wolstenholme A.J. and Rogers A.T. Parasitology. 2005, 131, S85-95 (Review).