The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core.
Equisetin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
Equisetin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
| References | Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites. Hazuda D. et al. , Antivir. Chem. Chemother. 1999, 10, 63. Equisetin, an antibiotic from Fusarium equiseti NRRL 5537, identified as a derivative of N-methyl-2,4-pyrollidone. Vesonder R.F., J. Antibiot. 1979, 32, 759. |
