SKU: E056  / 
    CAS Number: 1675-02-1

    Erythromycin C

    $109.73 - $384.02

    Erythromycin C (3''-O-demethylerythromycin) is a minor co-metabolite of Erythromycin.  Other metabolites include A, B, and D   Erythromycin C exhibits a narrower spectrum of antibiotic activity and is less active than A and B.  Erythromycin C is soluble in ethanol, methanol, DMF and DMSO but has limited water solubility. 

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    ApplicationResearchers were successful in reconstituting the erythromycin biosynthetic pathway in E. coli to produce Erythromycin C and D involving combining 2 tailoring genes and 14 genes involved in deoxysugar biosynthesis and attaching the megalomicin gene cluster (Peirú et al., 2005).
    ReferencesTsuii K and Goetz JF (1978)  HPLC as a rapid means of monitoring erythromycin and tetracycline fermentation processes.  J. Antibiot. 31:302  PMID 659328

    Kibwage O et al (1985)  Antibacterial activities of erythromycins A, B, C, and D and some of their derivatives.  Antimicrob. Agents Chemother.  28:630  PMID 4091529 

    Peiru S et al (2005)  Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.  Appl. Environ. Microbiol 71(5):2539-2547  PMID 15870344