Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound's polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.
Erythromycylamine is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
Erythromycylamine is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
| Molecular Formula | C37H70N2O12 |
| References | Erythromycin. VIII. Structure of dihydroerythronolide. Gerzon K. et al. J. Am. Chem. Soc. 1956, 78, 6396 Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136: LY237216), a new macrolide antibiotic derived from erythromycin. Counter F.T. et al. Antimicrob. Agents Chemother. 1991, 35, 1116. Dirithromycin: Introduction and historical development. Kirst H.A. Drugs Today 1995, 31, 89. |