Etamsylate is a haemostatic agent, used to arrest blood flow at the capillary level. It has antihemorrhagic properties. The compound is soluble in water.
|Mechanism of Action||
Etamsylate acts on the first step of hemostasis by improving platelet adhesiveness and restoring capillary resistance. Recent studies showed that Ethamsylate promotes P-selectin-dependent, platelet adhesive mechanisms.
|Eukaryotic Cell Culture Applications||
Researchers measured the expression of P-selectin in the membrane of SV40-transformed aortic rat endothelial cells. There was a significant increase in the percentage of platelets expressing P-selectin even at the lowest concentration (1 uM), with maximal enhancement at 10 uM (Alvarez-Guerra M et al, 2002).
Alvarez-Guerra M et al (2002) The hemostatic agent ethamsylate enhances P-selectin membrane expression in human platelets and cultured endothelial cells. Thromb. Res. 107(6):329-335 PMID 12565720
Garay RP, Chiavaroli C, and Hannaert P (2006) Therapeutic efficacy and mechanism of action of ethamsylate, a long-standing