Extracellular Death Factor (EDF) is the dramatic name given to an interesting linear pentapeptide produced by E. coli, first identified by Engelberg-Kulka and colleagues in 2007 and published in Science.
EDF is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
EDF is soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
| Mechanism of Action | EDF acts as a quorum sensing agent, regulating bacterial cell density by balancing the levels of toxin and antitoxin via mazEF-mediated cell death genes. |
| Molecular Formula | C27H36N10O10 |
| References | A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Kolodkin-Gal I. et al. Science 2007, 318, 652. |