Feglymycin is an amphoteric, 13-member, linear peptide featuring 3,5-dihydroxyphenylalanine and a terminal dicarboxylate amino acid, isolated from a Streptomyces in 1999. Feglymycin is a potent antiviral agent with antibacterial activity, including against MRSA.
Feglymycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Feglymycin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Feglymycin specifically inhibits the enzymes MurA and MurC and inhibits cell-to-cell transfer between HIV-infected T cells, uninfected CD4+ T cells, and the DC-SIGN-mediated viral transfer to CD4+ T cells. |
| Molecular Formula | C95H97N13O30 |
| References | Feglymycin, a novel inhibitor of the replication of the human immunodeficiency virus. Fermentation, isolation and structure elucidation. Vértesy L. et al. J. Antibiot. 1999, 52, 374. Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway. Rausch S. et al. Chembiochem. 2011, 12, 1171. Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120. Férir G. Virology 2012, 433, 308. |