Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.
Filipin complex is soluble in ethanol, methanol, DMF or DMSO.
Filipin complex is soluble in ethanol, methanol, DMF or DMSO.
| Molecular Formula | C35H58O11 (for Flipin III) |
| References | Filipin, an antifungal antibiotic: Isolation and properties. Whitfield G.B. et al. J. Am. Chem. Soc. 1955, 77, 4799. Separation of polyene antifungal antibiotics by high speed liquid chromatography. Mechlinski W. & Schaffner C.P. J. Chromatogr. 1974, 99, 619. Inhibition of fungi by filipin and its antagonism by sterols. Gottlieb D. et al. Phytopathology 1960, 50, 594. |
