Gageostatin A is an antimicrobial peptide (AMP) isolated from a marine strain of Bacillus subtilis. Gageostatin A is a linear lipopeptide composed of 7 peptides, and has shown initial bioactivity against pathogenic fungi, Gram-positive and Gram-negative bacteria, and cancer cell lines. Lipopeptides are nonribosomal oligopeptides made by large multienzyme complex and have a cyclic structure including β-amino or β-hydroyxl fatty acid that is integrated into the peptide moiety.
| Molecular Formula | C52H93N7O14 |
| Mechanism of Action | Lipopeptides may disrupt the cell membrane, thus affecting the transmembrane electric potential. |
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Cancer Applications
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Gageostatin A displayed cytotoxicity against 6 human cancer cell lines with GI50 values of 4.6-19.6 ug/ml. Superior antifungal and cytotoxicity was observed if Gageostatin A was mixed with Gageostatin B (Tareq et al, 2014). |
| References |
Tareq FS et al (2014). Gageostatins A–C, Antimicrobial linear lipopeptides from a marine Bacillus subtilis. Marine Drugs 12(2):871–885 PMID 24492520 |