Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator.
Galiellalactone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Galiellalactone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Recently Galiellalactone was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor. |
| References | The high-intrinsic Diels-Alder reactivity of (-)-galiellalactone; generating four quaternary carbon centers under mild monditions, von Nussbaum F. et al. Eur. J. Org. Chem. 2004, 2783. Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities. Kopcke B. et al. J. Antibiot. 2002, 55, 36. Synthesis of (-)-galiellalactone. Johansson M. et al. J. Antibiot. 2002, 55, 663. Inhibition of interleukin-6 signaling by galiellalactone. Weidler M. et al. FEBS Lett. 2000, 484, 1. Screening of basidiomycetes and ascomycetes for plant growth regulating substances. R. Hautzel & H. Anke, Z. Naturforsch. 1990, 45c, 1094. |