Gamithromycin is a semi-synthetic macrocyclic lactone belonging to the azalide class derived from erthyromycin, typified by azithromycin. The synthesis of gamithromycin involves a ring expansion using a Beckmann rearrangement to produce the 15-membered dibasic macrolide. Gamithromycin provides a broader spectrum of action, higher acid stability and improved bioavailability compared to older analogues of the erythromycin class and has been exclusively developed for animal health applications.
Gamithromycin is soluble in ethanol, methanol, DMF or DMSO.
Gamithromycin is soluble in ethanol, methanol, DMF or DMSO.
| Molecular Formula | C40H76N2O12 |
| References | Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefor. G.M. Bright US Patent 4,464,527 1985. Determination of the duration of antibacterial efficacy following administration of gamithromycin using a bovine Mannheimia haemolytica challenge model. Forbes A.B. et al. Antimicrob. Agents Chemother. 2011, 55, 831. |