SKU: G052  / 
    CAS Number: 158792-27-9

    Geninthiocin

    $277.35 - $970.71
    Geninthiocin is a thiopeptide antibiotic isolated from a Streptomyces sp. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

    Geninthiocin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
    Mechanism of ActionGeninthiocin is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance.
    Molecular FormulaC50H49N15O15S
    ReferencesMicrobial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84. Yun B-S. et al. J. Antibiot. 1994, 47, 969.

    Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators. Kahmann J.D. et al. EMBO J. 2003, 22, 1824.