Geninthiocin is a thiopeptide antibiotic isolated from a Streptomyces sp. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
Geninthiocin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
Geninthiocin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
| Mechanism of Action | Geninthiocin is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. |
| Molecular Formula | C50H49N15O15S |
| References | Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84. Yun B-S. et al. J. Antibiot. 1994, 47, 969. Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators. Kahmann J.D. et al. EMBO J. 2003, 22, 1824. |