SKU: H058  / 
    CAS Number: 91161-78-3

    hemi-Oxanthromicin

    $316.48 - $1,106.77

    hemi-Oxanthromicin is the monomer of (±)-oxanthromicin, first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. Unlike its co-metabolites, oxanthromicin and spiro-oxanthromicin, hemi-oxanthromicin does not inhibit mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells. hemi-Oxanthromicin was largely inactive in assays for antibacterial, antiviral, antimycobacterial and phytopathogenic activity (MIC >50 µg/mL). hemi-Oxanthromicin shows minimal cytotoxicity.

    Molecular Formula  C18H16O6
    References

    Bunbamrunga N et al (2018)  Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066. Phytochem. Lett. 25:109

    Salim A et al (2014)  Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Org. Biomol. Chem. 12:4872