Hesperidin is a flavonoid produced by citrus species, first published in 1943. Hesperidin has a broad pharmacological profile, including antihyperlipidemic, cardioprotective, antihypertensive and antidiabetic activities, mainly attributed to antioxidant activity and suppression of pro-inflammatory cytokine production. Hesperidin causes strongly dose-dependent G2/M phase cell cycle arrest. Hesperidin is also neuroprotective.
