Himandridine is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimia sp., a magnolia native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific reports of Himandridine’s biological activity, however the related himbacine and analogs inhibit muscarinic receptors with 10-fold selectivity for M2 over M1 receptors.
Brown RFC et al (1956) The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata and Himantandra belgraveana. Aust. J. Chem. 9:283
Chackalamannil S. et al (2004) Himbacine analogs as muscarinic receptor antagonists - effects of tether and heterocyclic variations. Bioorg. Med. Chem. Lett. 15:3967
Evans DA et al (20212) Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. New insights into intramolecular imine/enamine aldol cyclizations. J. Am. Chem. Soc. 134:8162