Himandridine is a piperidine alkaloid with a complex polycyclic scaffold first isolated from Galbulimia sp., a magnolia native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. There are no specific reports of Himandridine’s biological activity, however the related himbacine and analogs inhibit muscarinic receptors with 10-fold selectivity for M2 over M1 receptors.
| Molecular Formula | C30H37NO7 |
| References | Brown RFC et al (1956) The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata and Himantandra belgraveana. Aust. J. Chem. 9:283 Chackalamannil S. et al (2004) Himbacine analogs as muscarinic receptor antagonists - effects of tether and heterocyclic variations. Bioorg. Med. Chem. Lett. 15:3967 Evans DA et al (20212) Progress toward the syntheses of (+)-GB 13, (+)-himgaline, and himandridine. New insights into intramolecular imine/enamine aldol cyclizations. J. Am. Chem. Soc. 134:8162 |