Himbadine is a piperidine alkaloid with a polycyclic scaffold first isolated from Galbulimima sp. a magnolia species native to northern Australia and South East Asia, and reported in 1967 by Ritchie and co-workers, University of Sydney, Australia. The bioactivity of Himbadine has not been extensively investigated but its close structural relationship to other Galbulimima alkaloids suggests a possible affinity for muscarinic receptors.
| Molecular Formula | C21H31NO2 |
| References | Brown RFC et al (1956) The chemical constituents of Himantandra species. II. The isolation of the alkaloids of Himantandra baccata and Himantandra belgraveana. Aust. J. Chem. 9:283 Chackalamannil S. et al. (2004) Himbacine analogs as muscarinic receptor antagonists - effects of tether and heterocyclic variations. Bioorg. Med. Chem. Lett. 15:3967 Lan P et al (2018) Structures of new alkaloids from rain forest trees Galbulimima belgraveana and Galbulimima baccata in Papua New Guinea, Indonesia, and Northern Australia. ACS Omega 3:1912 Mander LN et al (1967) The chemical constituents of Galbulimima species IX. The structures of himbadine and alkaloid G.B. 13. Aust. J. Chem. 20:1473 |